TSLP Produced by Keratinocytes Promotes Allergen Sensitization through Skin and Thereby Triggers Atopic March in Mice
نویسندگان
چکیده
منابع مشابه
64 Effect of Formoterol on Eosinophil Trans-Basement Migration Induced by Interleukin-8-Stimulated Neutrophils
62 Keratinocytic Thymic Stromal Lymphopoietin Plays an Important Role in Epicutaneous Sensitization and the Atopic March Juan Manuel Leyva Castillo, MSc, Pierre Hener, Hua Jiang, PhD, Daniel Metzger, PhD, Pierre Chambon, PhD, and Mei Li, PhD. Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR-7104/INSERM U964/UdS, Illkirch CEDEX, France. Bac...
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62 Keratinocytic Thymic Stromal Lymphopoietin Plays an Important Role in Epicutaneous Sensitization and the Atopic March Juan Manuel Leyva Castillo, MSc, Pierre Hener, Hua Jiang, PhD, Daniel Metzger, PhD, Pierre Chambon, PhD, and Mei Li, PhD. Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR-7104/INSERM U964/UdS, Illkirch CEDEX, France. Bac...
متن کامل62 Keratinocytic Thymic Stromal Lymphopoietin Plays an Important Role in Epicutaneous Sensitization and the Atopic March
62 Keratinocytic Thymic Stromal Lymphopoietin Plays an Important Role in Epicutaneous Sensitization and the Atopic March Juan Manuel Leyva Castillo, MSc, Pierre Hener, Hua Jiang, PhD, Daniel Metzger, PhD, Pierre Chambon, PhD, and Mei Li, PhD. Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR-7104/INSERM U964/UdS, Illkirch CEDEX, France. Bac...
متن کاملSelective Ablation of Ctip2/Bcl11b in Epidermal Keratinocytes Triggers Atopic Dermatitis-Like Skin Inflammatory Responses in Adult Mice
BACKGROUND Ctip2 is crucial for epidermal homeostasis and protective barrier formation in developing mouse embryos. Selective ablation of Ctip2 in epidermis leads to increased transepidermal water loss (TEWL), impaired epidermal proliferation, terminal differentiation, as well as altered lipid composition during development. However, little is known about the role of Ctip2 in skin homeostasis i...
متن کاملSkin-Derived TSLP Triggers Progression from Epidermal-Barrier Defects to Asthma
Asthma is a common allergic lung disease frequently affecting individuals with a prior history of eczema/atopic dermatitis (AD); however, the mechanism underlying the progression from AD to asthma (the so-called "atopic march") is unclear. Here we show that, like humans with AD, mice with skin-barrier defects develop AD-like skin inflammation and are susceptible to allergic asthma. Furthermore,...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2013
ISSN: 0022-202X
DOI: 10.1038/jid.2012.239